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The No. 2 seed Iowa State Cyclones (28-7) and the No. 7 seed Kentucky Wildcats (22-13) will square off in the NCAA Tournament with a spot in the Sweet 16 of the Midwest Region bracket on the line on Sunday at Enterprise Center, tipping off at 2:45 p.m. ET.
Sunday's matchup between the Cyclones and the Wildcats sees the Cyclones as 5.5-point favorites. The matchup's point total is 146.5.
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Iowa State vs. Kentucky Odds and Game Info
- Game day: Sunday, March 22, 2026
- Game time: 2:45 p.m. ET
- TV channel: CBS
- Location: St. Louis, Missouri
- Arena: Enterprise Center
- Live stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Iowa State vs. Kentucky Odds and Prediction
- Spread favorite: Iowa State (-5.5)
- Moneyline: Iowa State (-234), Kentucky (+189)
- Total: 146.5 points
Pick ATS:Iowa State (-5.5)
- Pick OU: Over (146.5)
- Prediction: Iowa State 80, Kentucky 72
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Iowa State vs. Kentucky Comparison
| Iowa State Rank | Iowa State Stat | Kentucky Stat | Kentucky Rank | |
|---|---|---|---|---|
| 46th | 82.5 | Points Scored | 81.0 | 65th |
| 13th | 65.4 | Points Allowed | 74.1 | 187th |
| 19th | 17.4 | Assists | 16.1 | 51st |
| 70th | 9.9 | Turnovers | 9.9 | 70th |
| 18th | 49.1% | Field Goal % | 46.6% | 88th |
| 83rd | 42.7% | Field Goal % Allowed | 42.5% | 74th |
Iowa State Key Players
- The Cyclones scoring leader is Milan Momcilovic, who averages 17.1 per contest to go with 3.1 rebounds and 1.0 assist.
- Joshua Jefferson leads Iowa State in rebounding, averaging 7.4 per game, while Tamin Lipsey leads the team in assists, distributing an average of 4.9 in each contest.
- The Cyclones get the most three-point shooting production out of Momcilovic, who makes 3.7 threes per game.
- Lipsey is Iowa State's leader in steals, averaging 2.2 steals per game, while Blake Buchanan leads them in blocks with 1.0 per contest.
Kentucky Key Players
- Otega Oweh is at the top of the Wildcats scoring leaderboard with 18.7 points per game. Oweh also grabs 4.7 rebounds and dishes out 2.7 assists per game.
- Malachi Moreno has a stat line of 6.3 rebounds, 7.9 points and 1.7 assists per game for Kentucky to take the top rebound spot on the team. Denzel Aberdeen has the top spot for assists with 3.5 per game, adding 13.3 points and 2.5 rebounds per contest.
- Collin Chandler is the top shooter from distance for the Wildcats, hitting 2.0 threes per game.
- Oweh (1.7 steals per game) is the steal leader for Kentucky while Moreno (1.5 blocks per game) is the block leader.
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