49ers vs. Colts Dec. 22 Viewing Options: TV, Live Stream

On Monday, December 22, 2025, the San Francisco 49ers (10-4) visit the Indianapolis Colts (8-6) at Lucas Oil Stadium and will look to extend a four-game winning streak.

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49ers vs. Colts: Dec. 22 Viewing Options

• When: Monday, December 22, 2025 at 8:15 p.m. ET
• Where: Lucas Oil Stadium in Indianapolis, Indiana
• TV: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Listen to the game on 107.5 The Fan

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49ers vs. Colts Insights

• The 49ers have put an average of 24.6 points per game on the board this season, 3.0 more than the 21.6 the Colts have surrendered.
• The Colts have put an average of 28.0 points per game on the board this year, 7.1 more than the 20.9 the 49ers have surrendered.
• San Francisco's offense has averaged 347.5 yards per game this season, within 4.8 yards of the 342.7 Indianapolis' defense has allowed. SF picks up 5.5 yards per play and Indy gives up 5.5.
• San Francisco's defense has allowed 333.6 yards per game this season, 24.3 yards fewer than the 357.9-yard average from Indianapolis' offense. Indianapolis picks up 6.2 yards per play and San Francisco gives up 5.7.
• The Colts have allowed opposing rushing attacks to average 95.1 yards per game in 2025 compared to the 101.4 yards the 49ers offense has averaged on the ground per contest.
• The Colts are averaging 128.9 rushing yards per game, 22.8 more than the 49ers are allowing (106.1).
• San Francisco has turned the ball over 19 times this season, while Indianapolis has 18 takeaways.
• This year San Francisco has forced 14 turnovers, compared to the 16 times Indianapolis has turned the ball over.

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49ers' Upcoming Schedule

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Colts' Upcoming Schedule