Jonathan Taylor Week 16 Preview vs. the 49ers

Indianapolis Colts running back Jonathan Taylor will be up against the San Francisco 49ers and their 12th-ranked run defense in Week 16, with kickoff at 8:15 p.m. ET on Monday.

Taylor has taken 272 carries for a team-best 1,443 yards (103.1 ypg) this season while working his way into the end zone 16 times. Taylor has added 38 receptions for 318 yards, good for 22.7 yards per game and two receiving touchdowns.

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Taylor vs. the 49ers

• Taylor vs the 49ers (since 2021): 1 GP / 107 RUSH YPG / 1 RUSH TD
• The 49ers have given up 100 or more yards to only two opposing rushers during the 2025 season.
• San Francisco has allowed one or more rushing TDs to eight opposing players this year.
• The 49ers have allowed two or more rushing TDs to only one opposing rusher this season.
• Taylor will square off against the NFL's 12th-ranked run defense this week. The 49ers concede 106.1 yards on the ground per contest.
• Opponents of the 49ers have put up nine touchdowns on the ground (0.6 per game). The 49ers' defense is third in the league in that category.

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Taylor Rushing Insights

• Taylor hit the over on his rushing yards total set by oddsmakers in seven of his 14 opportunities this season (50.0%).
• The Colts have passed 54.5% of the time and run 45.5% this season. They rank eighth in the NFL in scoring.
• His team has attempted 372 rushes this season. He's taken 272 of those carries (73.1%).
• In seven games this year, Taylor has run for at least one touchdown, including five games with multiple rushing TDs.
• He has 40.9% of his team's 44 offensive touchdowns this season (18).
• He has 58 red zone rushing carries (68.2% of his team's rushing attempts inside the red zone).

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Taylor's Recent Performance