Alec Pierce Week 16 Preview vs. the 49ers

Alec Pierce has a favorable matchup when his Indianapolis Colts play the San Francisco 49ers in Week 16 (Monday, 8:15 p.m. ET). The 49ers concede 227.6 passing yards per game, 10th-worst in the NFL.

Pierce's 39 grabs are good enough for a team-best 785 total yards (and an average of 65.4 per game) and two scores. He has been targeted 68 times.

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Pierce vs. the 49ers

• Pierce vs the 49ers (since 2021): No games
• San Francisco has allowed three opposing receivers to rack up 100 or more receiving yards in a game in the 2025 season.
• The 49ers have allowed 24 opposing players to record a TD reception against them this year.
• San Francisco has allowed just one player to register at least two TD catches against it in a matchup on the season.
• The 49ers give up 227.6 passing yards per game, the NFL's 23rd-ranked pass defense this season.
• The 49ers' defense is 21st in the NFL by conceding 1.8 passing touchdowns per game to opponents (25 total passing TDs).

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Pierce Receiving Insights

• In 10 of 12 games this season, Pierce has topped his prop for receiving yards.
• Pierce has been targeted on 68 of his team's 445 passing attempts this season (15.3% target share).
• He has 785 receiving yards on 68 targets to rank second in league play with 11.5 yards per target.
• Pierce has had a touchdown catch in two of 12 games this year. He hauled in only one TD reception in each of those games.
• He has two total touchdowns this season (4.5% of his team's 44 offensive TDs).
• Pierce has been targeted five times in the red zone (8.2% of his team's 61 red zone pass attempts).

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Pierce's Recent Performance