Alec Pierce Week 16 Preview vs. the 49ers

Alec Pierce has a decent matchup when his Indianapolis Colts play the San Francisco 49ers in Week 16 (Monday, 8:15 p.m. ET). The 49ers have allowed 227.6 passing yards per game, 22nd in the NFL.

Pierce has put up a team-high 785 yards (on 39 catches) with two TDs this season. He's been targeted 68 times, resulting in 65.4 yards per game.

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Pierce vs. the 49ers

• Pierce vs the 49ers (since 2021): No games
• Three players have racked up 100 or more receiving yards in a game against San Francisco in the 2025 season.
• The 49ers have allowed 24 opposing players to record a TD reception against them this year.
• San Francisco has allowed at least two TD receptions to only one opposing player on the season.
• The 49ers surrender 227.6 passing yards per game, the NFL's 22nd-ranked pass defense this season.
• So far this season, the 49ers have surrendered 25 passing TDs to opponents, averaging 1.8 per game. That ranks 25th in league play.

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Pierce Receiving Insights

• Pierce, in 10 of 12 games, has gone over on his receiving yards prop bet.
• Pierce has received 15.3% of his team's 445 passing attempts this season (68 targets).
• He has 785 receiving yards on 68 targets to rank third in NFL play with 11.5 yards per target.
• Pierce has had a touchdown catch in two of 12 games this year. He reeled in only one TD reception in each of those games.
• He has two total touchdowns this season (4.5% of his team's 44 offensive TDs).
• Pierce (five red zone targets) has been targeted 8.2% of the time in the red zone (61 total red zone pass attempts on the team).

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Pierce's Recent Performance