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The Indiana Pacers (2-13) are heavy underdogs (+13.5) as they attempt to break an eight-game road slide when they square off against the Cleveland Cavaliers (10-6) on Friday, November 21, 2025 at Rocket Arena. The contest airs at 7 p.m. ET on Amazon Prime Video.
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Listen to the game on Newsradio WTAM 1100
Cavaliers vs. Pacers Predictions for Friday
Our computer model for this encounter expects a final score of Cavaliers 126, Pacers 108.
- Moneyline Pick: Cavaliers (-935)
- Total Pick: Under 239.5 (computer predicts 234.6 points)
- Pick ATS: Cavaliers (-13.5)
Recent Cavaliers vs. Pacers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 5/13/2025 | Cavaliers | -8 | 231 | -316 | +254 | 114-105 IND |
| 5/11/2025 | Cavaliers | -5.5 | 230.5 | -230 | +189 | 129-109 IND |
| 5/9/2025 | Cavaliers | -5 | 232 | -220 | +182 | 126-104 CLE |
| 5/6/2025 | Cavaliers | -7.5 | 229 | -323 | +258 | 120-119 IND |
| 5/4/2025 | Cavaliers | -8 | 229.5 | -368 | +292 | 121-112 IND |
| 4/13/2025 | Pacers | -7 | 226.5 | -274 | +221 | 126-118 IND |
| 4/10/2025 | Pacers | -9.5 | 234.5 | -435 | +334 | 114-112 IND |
| 1/14/2025 | Cavaliers | -8.5 | 231.5 | -353 | +278 | 127-117 CLE |
| 1/12/2025 | Cavaliers | -9 | 239 | -397 | +312 | 108-93 IND |
Cavaliers 2025-26 Betting Trends
- Cleveland's ATS record is 6-10-0 this season.
- The Cavaliers are 1-0 against the spread so far this season when playing as at least 13.5-point favorites.
- Cleveland's games have hit the over in eight out of 15 opportunities (53.3%).
- The Cavaliers have won nine, or 64.3%, of the 14 games they've played as favorites this season.
- Cleveland has not entered a game this season with shorter moneyline odds than -935.
Pacers 2025-26 Betting Trends
- Indiana's ATS record is 6-9-0 this year.
- Of Indiana's 15 games with a set total, six have hit the over (40%).
- The Pacers are 2-11 in games they were the underdog on the moneyline (winning 15.4% of those games).
- Indiana has not yet played as a moneyline underdog of +617 or longer.
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Cavaliers vs. Pacers Injury Report
Cavaliers
Cavaliers:
Jaylon Tyson: Questionable (Illness),
Sam Merrill: Out (Hand),
Darius Garland: Questionable (Toe),
Jarrett Allen: Questionable (Finger),
Max Strus: Out (Foot)
Pacers
Pacers:
Obi Toppin: Out (Foot),
Kam Jones: Out (Back),
Aaron Nesmith: Out (Knee),
Quenton Jackson: Out (Hamstring),
Johnny Furphy: Out (Ankle),
Tyrese Haliburton: Out For Season (Achilles)
Cavaliers vs. Pacers Game Time and TV Channel
- Game day: Friday, November 21, 2025
- Game time: 7 p.m. ET
- TV channel: Amazon Prime Video
- Location: Cleveland, Ohio
- Arena: Rocket Arena
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