The Indiana Pacers (2-13) visit the Cleveland Cavaliers (10-6) after losing eight straight road games. The Cavaliers are heavy favorites by 14 points in the matchup, which begins at 7 p.m. ET on Friday, November 21, 2025.
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Listen to the game on Newsradio WTAM 1100
Cavaliers vs. Pacers Predictions for Friday
Our computer projection model for this encounter predicts a final score of Cavaliers 126, Pacers 108.
- Moneyline Pick: Cavaliers (-885)
- Total Pick: Under 236.5 (computer predicts 234.6 points)
- Pick ATS: Cavaliers (-14)
Recent Cavaliers vs. Pacers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 5/13/2025 | Cavaliers | -8 | 231 | -316 | +254 | 114-105 IND |
| 5/11/2025 | Cavaliers | -5.5 | 230.5 | -230 | +189 | 129-109 IND |
| 5/9/2025 | Cavaliers | -5 | 232 | -220 | +182 | 126-104 CLE |
| 5/6/2025 | Cavaliers | -7.5 | 229 | -323 | +258 | 120-119 IND |
| 5/4/2025 | Cavaliers | -8 | 229.5 | -368 | +292 | 121-112 IND |
| 4/13/2025 | Pacers | -7 | 226.5 | -274 | +221 | 126-118 IND |
| 4/10/2025 | Pacers | -9.5 | 234.5 | -435 | +334 | 114-112 IND |
| 1/14/2025 | Cavaliers | -8.5 | 231.5 | -353 | +278 | 127-117 CLE |
| 1/12/2025 | Cavaliers | -9 | 239 | -397 | +312 | 108-93 IND |
Cavaliers 2025-26 Betting Trends
- So far this season, Cleveland has put together a 6-10-0 record against the spread.
- Cleveland's games have gone over the point total in eight out of 15 opportunities (53.3%).
- This season, the Cavaliers have been favored 14 times and won nine, or 64.3%, of those games.
- Cleveland has not entered a game this season with shorter moneyline odds than -885.
Pacers 2025-26 Betting Trends
- Indiana is 6-9-0 against the spread this year.
- Indiana's games have gone over the point total six out of 15 times (40%).
- The Pacers have been the moneyline underdog 13 total times this season. They've finished 2-11 in those games.
- Indiana has not yet played as a moneyline underdog of +595 or longer.
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Cavaliers vs. Pacers Injury Report
Cavaliers
Cavaliers:
Max Strus: Out (Foot),
Jaylon Tyson: Day-To-Day (Illness),
Sam Merrill: Day-To-Day (Hand),
Darius Garland: Day-To-Day (Toe)
Pacers
Pacers:
Tyrese Haliburton: Out For Season (Achilles),
Obi Toppin: Out (Foot),
Kam Jones: Out (Back),
Aaron Nesmith: Out (Knee),
Quenton Jackson: Day-To-Day (Hamstring),
Johnny Furphy: Day-To-Day (Ankle)
Cavaliers vs. Pacers Game Time and TV Channel
- Game day: Friday, November 21, 2025
- Game time: 7 p.m. ET
- TV channel: Amazon Prime Video
- Location: Cleveland, Ohio
- Arena: Rocket Arena
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