Photo: Andy Lyons / Getty Images Sport / Getty Images
The No. 19 Louisville Cardinals (7-2) take on a fellow ACC opponent when they host the Clemson Tigers (4-5) on Friday, November 14, 2025 at L&N Federal Credit Union Stadium.
Watch college football live without cable. Stream ACC, SEC, ESPN and more with Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and start watching college football games now.
Louisville vs. Clemson Matchup Info
- Game date: Friday, November 14, 2025
- Game time: 7:30 p.m. ET
- Location: Louisville, Kentucky
- Venue: L&N Federal Credit Union Stadium
- TV channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
Stop missing games and start streaming college football right now on Fubo.
Louisville vs. Clemson Odds and Prediction
- Spread favorite: Cardinals (-2.5)
- Moneyline: Cardinals (-135), Tigers (+114)
- Total: 51.5 points
- Pick ATS: Louisville (-2.5)
- Pick OU: Over (51.5)
- Prediction: Louisville 31, Clemson 21
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
Looking for officially licensed gear? Fanatics has jerseys, hats, apparel, memorabilia, trading cards, collectibles and more.
Louisville vs. Clemson Betting Records and Insights
- Louisville has covered three times in nine games with a spread this season.
- Clemson has put together a 3-6-0 record against the spread this season.
- The Cardinals have covered the spread twice this season (2-6 ATS) when playing as at least 2.5-point favorites.
- So far this season, five of Louisville's nine games have gone over the point total.
- So far this season, four of Clemson's nine games with a set number have gone over the point total.