Photo: Andy Lyons / Getty Images Sport / Getty Images
The No. 16 Louisville Cardinals (6-1) hit the road for an ACC battle against the Virginia Tech Hokies (3-5) on Saturday, November 1, 2025 at Lane Stadium.
Watch college football live without cable. Stream ACC, SEC, ESPN and more with Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and start watching college football games now.
Louisville vs. Virginia Tech Matchup Info
- Game date: Saturday, November 1, 2025
- Game time: 3 p.m. ET
- Location: Blacksburg, Virginia
- Venue: Lane Stadium
- TV channel: The CW
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
Stop missing games and start streaming college football right now on Fubo.
Louisville vs. Virginia Tech Odds and Prediction
- Spread favorite: Cardinals (-10)
- Moneyline: Cardinals (-386), Hokies (+303)
- Total: 52.5 points
- Pick ATS: Louisville (-10)
- Pick OU: Over (52.5)
- Prediction: Louisville 37, Virginia Tech 19
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
Looking for officially licensed gear? Fanatics has jerseys, hats, apparel, memorabilia, trading cards, collectibles and more.
Louisville vs. Virginia Tech Betting Records and Insights
- Louisville has covered twice in seven games with a spread this season.
- Virginia Tech has a record of just 2-6-0 against the spread this season.
- The Cardinals have been favored by 10 points or more this season four times and failed to cover in all four.
- The Hokies have not covered the spread when an underdog by 10 points or more this season (in one opportunity).
- In Louisville's seven games this season, the combined scoring has gone over the point total four times.
- Virginia Tech and its opponent have combined to hit the over four out of eight times this year.