The No. 19 Louisville Cardinals (5-1) meet a conference opponent when they host the Boston College Eagles (1-6) on Saturday, October 25, 2025 at L&N Federal Credit Union Stadium in an ACC battle.
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Louisville vs. Boston College Matchup Info
- Game date: Saturday, October 25, 2025
- Game time: 7:30 p.m. ET
- Location: Louisville, Kentucky
- Venue: L&N Federal Credit Union Stadium
- TV channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Louisville vs. Boston College Odds and Prediction
- Spread favorite: Cardinals (-25.5)
- Moneyline: Cardinals (-3030), Eagles (+1330)
- Total: 54.5 points
- Pick ATS: Louisville (-25.5)
- Pick OU: Over (54.5)
- Prediction: Louisville 47, Boston College 9
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Louisville vs. Boston College Betting Records and Insights
- Louisville has covered twice in six chances against the spread this season.
- Boston College has covered twice in seven matchups with a spread this season.
- The Cardinals have been favored by 25.5 points or more this season twice, and failed to cover both times.
- Louisville games have hit the over three out of six times this season.
- In Boston College's seven contests this season, the combined scoring has gone over the point total four times.