La. Tech vs. WKU Football Prediction & Odds - Oct. 21

Marshall v Notre Dame

Photo: Michael Reaves / Getty Images Sport / Getty Images

The Louisiana Tech Bulldogs (4-2) host a CUSA clash against the Western Kentucky Hilltoppers (5-2) on Tuesday, October 21, 2025 at Joe Aillet Stadium.

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Louisiana Tech vs. Western Kentucky Matchup Info

  • Game date: Tuesday, October 21, 2025
  • Game time: 7:30 p.m. ET
  • Location: Ruston, Louisiana
  • Venue: Joe Aillet Stadium
  • TV channel: CBS Sports Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Louisiana Tech vs. Western Kentucky Odds and Prediction

  • Spread favorite: Bulldogs (-3.5)
  • Moneyline: Bulldogs (-169), Hilltoppers (+142)
  • Total: 50.5 points
  • Pick ATS: Louisiana Tech (-3.5)
  • Pick OU: Under (50.5)
  • Prediction: Louisiana Tech 33, Western Kentucky 15

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Louisiana Tech vs. Western Kentucky Betting Records and Insights

  • Louisiana Tech has won five games against the spread this season, while failing to cover once.
  • Western Kentucky is 5-2-0 ATS this year.
  • The Bulldogs have been favored by 3.5 points or more four times this season, and covered the spread in three of those games.
  • The Hilltoppers have been an underdog by 3.5 points or more this season once, and failed to cover the spread.
  • Louisiana Tech games have gone over the point total just once this season.
  • In 2025, three Western Kentucky games have hit the over.

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