The Louisville Cardinals (1-0) and the James Madison Dukes (1-0) meet at L&N Federal Credit Union Stadium on Friday, September 5, 2025.
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Louisville vs. James Madison Matchup Info
- Game date: Friday, September 5, 2025
- Game time: 7 p.m. ET
- Location: Louisville, Kentucky
- Venue: L&N Federal Credit Union Stadium
- TV channel: ESPN2
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Louisville vs. James Madison Odds and Prediction
- Spread favorite: Cardinals (-14.5)
- Moneyline: Cardinals (-685), Dukes (+489)
- Total: 55.5 points
- Pick ATS: Louisville (-14.5)
- Pick OU: Over (55.5)
- Prediction: Louisville 38, James Madison 21
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Louisville vs. James Madison Betting Records and Insights
- Louisville is winless against the spread this season (0-1-0).
- James Madison has won one game against the spread this season.
- The Cardinals have not covered the spread when favored by 14.5 points or more this season (in one opportunity).
- All Louisville games have hit the over this season.
- James Madison has yet to hit the over in any game this season.